CPS online exam for peptide certification by peptidesociety | Jan 21, 2023 | Uncategorized 0% 0 votes, 0 avg 83 Essential Knowledge in the Clinical Use of Peptides Class Clinical Peptide Society Please enter the information below. 1 / 90 1. Some peptides are A) Hormones B) Neurotransmitters C) Signaling molecules D) Antimicrobial E) All of above 2 / 90 2. According to the Human Proteome Map how many peptides do we approximately have? A) 3000 A) 30,000 A) 300,000 A) 3,000,000 3 / 90 3. A peptide bond between 2 amino acids is formed by what reaction A) Hydration reaction B) Dehydration reaction C) Carboxyl reaction D) Photosynthesis 4 / 90 4. Epithalon has been shown to increase the telomeres by 5% 10% 20% 33% 5 / 90 5. Epithalon has been shown in a mice and rat study Increase the life span of both animals but increased the development of tumors Decrease the life span of both animals but increased the development of tumors Increase the life span of both animals and decreased the development of tumors Decrease the life span of both animals and decreased the development of tumors 6 / 90 6. Peptides are signaling molecules True False 7 / 90 7. A peptide bond is A) Between a carboxyl group of one amino acid and another carboxyl group of another amino acid B) Between an amino group of one amino acid and another amino group of another amino acid C) Between a carboxyl group on one amino acid and amino group of another amino acid D) Between a carboxyl group on one amino acid and the R side chain of another amino acid 8 / 90 8. Peptides are Steroid structure Made of amino acids that are over 100 amino acids long Made of amino acids with glycosaminoglycan None of the above 9 / 90 9. What is the most common receptor for peptides? Tyrosine kinase receptor Ion channel receptor G Protein coupled receptor All of the above 10 / 90 10. Which hormones are peptide or peptides? ACTH Oxytocin Estradiol Testosterone A and B 11 / 90 11. For an acute problem (new infection) a dose of thymulin can be a. Need to take Zinc 30-50 mg a day b. 5-6 mg SQ once a day with zinc until one gets better c. 10-12 mg IV push over 10 minutes with zinc d. All of the above 12 / 90 12. In the clinical trials with Thymulin in Rheumatoid Arthritis that used a dose of 5 mg SQ for weeks and then 3 times a week for 6 months showed... a. No improvement b. Improvement c. Made it worse 13 / 90 13. Thymosin is not zinc dependent True False 14 / 90 14. Thymosin Alpha 1 dose protocol for Hepatitis has been 1.6 mg SQ 2 times a week. True False 15 / 90 15. Thymosin Alpha mechanism of action is improving the T cell maturation, increase the cytokine response and increase NK cells, dendritic cells and macrophages. True False 16 / 90 16. AOD9604 can help with weight loss and increase growth hormone. True False 17 / 90 17. In the Bremelanotide trials there was no side effects of nausea, flushing, or headaches? True False 18 / 90 18. Recommended starting dose of MK-667 is a. 2.5 mg b. 12.5 mg c. 25 mg d. 100 mg 19 / 90 19. MK-667 or Ibutamoren has side effects of a. Increase hunger b. Increase glucose c. Heart failure d. All of the above 20 / 90 20. MOTS-c can increase the biogenesis of the mitochondria via a. PGC-1 (Peroxisome proliferator activated receptor gamma coactivator 1 -alpha) b. AMPK c. Tyrosine Kinase 21 / 90 21. MOTS-c can help generate heat from brown fat by? a. Protein called Uncoupling Factor 1 b. Improving Insulin Resistance c. Reducing myostatin levels d. Adrenaline e. All of the above 22 / 90 22. In a study in mice given a high fat diet MOTS-c improved obesity by? a. Increasing Nitric Oxide b. Improving insulin resistance c. Decrease appetite d. All of the above 23 / 90 23. Although no formal GHK-cu dosing for cancer has been established, anecdotal results have been observed at: a. 2.5mg SQ 3 times per week b. 0.5mg IM once weekly c. 20mg IV bolus dose d. None of the above 24 / 90 24. An acceptable TB4 dose is: a. 750mcg SQ daily b. 7.5mg IM weekly c. 10mg IV TIW (three times a week) d. 700mcg SQ weekly 25 / 90 25. As we age MOTS-c levels are ____________ compared to younger subjects a. Higher b. Lower c. No change 26 / 90 26. Thymosin Beta 4 has not shown any effect in angiogenesis, neurogenesis, axonal outgrowth and oligodendrogenesis? True False 27 / 90 27. Although multiple dosing regimens have been studied with TA1, an accepted dosing regimen in cancer management is: a. 10mg IM weekly b. 1.6mg SQ 2 times a week c. 5mg IV daily d. None of the above 28 / 90 28. Thymosin Alpha 1 has been shown to reduce mortality in the treatment of sepsis True False 29 / 90 29. Thymosin Beta 4 has not been able to show increase in myelination or increase in oligodendrocyte cells? True False 30 / 90 30. Thymosin beta 4 and Thymosin alpha 1 has been shown together to reduce amyloid plaque? True False 31 / 90 31. TA1 has not been studied as a treatment for which of these infectious diseases? a. Hepatitis C b. CMV c. Hepatitis B d. Has been studied for all of the above 32 / 90 32. Which of these are considered thymic peptide (Thymosin)? a. Thymosin alpha 1 b. Thymosin beta 4 c. Thymulin d. All of the above 33 / 90 33. GHK-cu’s anticancer mechanism of action is: a. Increased copper accumulation in cancer cells, resulting in cytotoxicity b. Transmembrane cancer cell destabilization c. Direct GHK peptide effects on cancer cell growth d. Suppression of RNA production in overexpressed cancer genes 34 / 90 34. Botox peptides should be used before GHK copper True False 35 / 90 35. Which of the following doses of Metenkephalin has been studied clinically? a. 1gm/kg b. 2gm/kg c. 250mcg/kg d. 500mcg/kg 36 / 90 36. Metenkephalin stimulates which of the following cancer inhibitory pathways? a. P16 b. P23 c. P21 d. A and C e. All of the above 37 / 90 37. Which of these is not a cell growth cycle checkpoint? a. G1-S transition b. G2-M transition c. G0-S transition d. Exit-M Transition 38 / 90 38. Which Immune cells are involved with autoimmune disease? a. Decrease in T regulatory cells b. Increase in T regulatory cells c. Increase in T effector cells d. A and C only e. All of the above 39 / 90 39. This peptide can block the release of IL6, IL12, NF-Kb, TNFa and can increase regulatory T cells. a. TB4 b. MetEnkephalin c. DSIP d. GHK-CU 40 / 90 40. This T helper cell population plays a role in eradicating extracellular fungi and bacteria. They have also been identified as playing a major role in autoimmune diseases: a. TH2 b. TH17 c. TH1 d. TH8 41 / 90 41. Which of these interleukins is responsible for promoting a tolerogenic environment? a. IL 15 b. IL 17 c. IL 10 d. IL18 42 / 90 42. What type of T cell promotes a tolerogenic environment and can be of benefit in the treatment of autoimmune diseases? A) T helper cells B) T regulatory cells C. Cytotoxic T cells D. Clonal T cells 43 / 90 43. Selank dosing A) 100 mcg pill once to twice a day B) 200 mcg pill once to twice a day C) 75 mcg intranasal 1-2 spray once to BID D) 75 mcg pill once to twice a day 44 / 90 44. Selank can be delivered A) Oral B) Intranasal C) Subcutaneous D) All of the above E) B and C 45 / 90 45. Selank influences the gene expression of what A) GABA erigic system B) Immunoglubulin genes C) Genes involved in the vascular system D) Genes involved in regulating intracellular calcium E) All above 46 / 90 46. True or False Selank increases BDNF True False 47 / 90 47. Selank main effect is that it helps with A) Anxiety B) Weight loss C) Tanning D) Improve libido 48 / 90 48. Semax can be delivered A) Oral B) Intranasal C) Subcutaneous D) All of the above E) B and C 49 / 90 49. Semax improved recovery in stroke, what doses did they use? A) 12 mg for moderate stroke B) 18 mg for severe stroke C) 1000 mg for all strokes D) A and B 50 / 90 50. Semax is analogue of which hormone A) Melanocyte Stimulating hormone B) ACTH C) Corticotropin releasing hormone D) Oxytocin 51 / 90 51. Semax was discovered in what country? A) USA B) Australia C) Russia D) Brazil 52 / 90 52. Cerebrolsyin is mixed in 250 cc of normal saline True False 53 / 90 53. Dosing of Cerebrolysin in studies A) 10 ml IV infusion 5 times a week B) 20 ml IV infusion 5 times a week C) 30 ml IV infusion 5 times a week D) All of above 54 / 90 54. Cerebrolysin in first degree relatives with Alzhemier’s showed after 1 month of Cerebrolysin at 20 ml/ day for 1 month A) Improvement of cognitive function B) No change in cognitive function C) Decline in cognitive function 55 / 90 55. Combination of Cerebrolysin and Donepezil (Aricept) showed A) Decline in Brain Derived Neurtrophic Factor (BDNF) B) No change in BDNF C) Increase in BDNF 56 / 90 56. In the meta analysis of 6 randomized double blind placebo controlled studies on Cerebrolysin for mild to moderate Alzheimer’s disease, Cerebrolysin did not improve on cognitive function. True False 57 / 90 57. Cerebrolysin was registered as a drug in Austria since 1954, which is a false statement? A) Many clinical trials since 1954 B) Is approved in the USA C) Has been approved in 44 countries D) Is approved for the treatment for dementia and stroke 58 / 90 58. Cerebrolysin was discovered by An Austrian professor in 1949 and it contains A) A peptide called Cerebrolysin B) Growth Factors C) Mixtures of many peptides and growth factors D) Brain Derived Neurotrophic factor 59 / 90 59. Typical dosing with BPC 157 for an acute musculoskeletal injury would be? A) 100 mcg SQ once a day x 1 day B) 200 mcg SQ once a day X 2 days C) 300 mcg SQ once a day x 3 days D) 1000 mcg SQ BID for 4-5 days 60 / 90 60. BPC 157 has no role in helping with the recovery of traumatic brain injury True False 61 / 90 61. BPC 157 can help with chemical or alkali burns True False 62 / 90 62. In animal phase 2 study the lethal dose of BPC 157 to kill 1% was A) 2 mg B) 10 mg C) 1000 mg D) No dose was found 63 / 90 63. There is an animal study showing that BPC 157 healed a transected sciatic nerve True False 64 / 90 64. BPC 157 has been shown to A) Increase pressure in lower esophageal sphincter (LES) B) Increase pressure in the pyloric sphincter C) Helps in healing fistulas D) Normalize the LES pressure with NSAID- Nonsteroidal anti-inflammatory drugs E) All of the above 65 / 90 65. The mechanism of action of BPC 157 might be A) Increase Growth Hormone receptors B) Increase Nitric oxide C) Increase the expression of early growth response 1 gene D) Regulates the extracellular signal regulated kinases 1 and 2 E) All of the above 66 / 90 66. BPC 157 increases which type of collagen A) Type 1 B) Type 2 C) Type 3 D) Type 4 67 / 90 67. True or False BPC-157 has been shown in animal study to heal a detached achilles True False 68 / 90 68. What is the common dose of CJC-1295 non Dac with ipamorelin? A) 200 micrograms IM at bedtime B) 2000 micrograms by mouth at bedtime C) 200 micrograms SQ M-F at bedtime D) 2000 micrograms by mouth at bedtime M-F 69 / 90 69. Tesamorelin recommended dosing is A) 1 mg sq in the AM time every day B) 1 mg sq at bedtime every night C) 1 mg sq in the AM time 5-6 times a week D) 1 mg sq at bedtime 5-6 times a week 70 / 90 70. Which peptides stimulates the Ghrelin receptor? A) CJC 1295 B) Ipamorelin C) Semorelin D) Tesamorelin E) B, C, D 71 / 90 71. Growth hormone releasing peptides (GHRP) interacting with the Ghrelin receptor stimulates what in the pituitary to release Growth hormone? A) Cyclic AMP B) Calcium C) Magnesium D) Zinc 72 / 90 72. In a 2006 study with CJC-1295 with DAC looking at lipodystrophy in HIV patients there was one adverse side effect A) Stroke B) Kidney Failure C) Heart attack D) Liver Failure 73 / 90 73. Bremelanotide PT-141 is a derivative of which peptide A) Melanotan 1 B) Melanotan 2 C) ACTH D) None of the above 74 / 90 74. CJC-1295 an analog of A) Growth hormone releasing hormone B) Growth hormone releasing peptide C) Both D) Neither 75 / 90 75. The advantages of using peptides to stimulate growth hormone versus using human growth hormone A) Release of 5 growth hormones from the pituitary gland B) Growth hormone releasing peptide C) Both D) Neither 76 / 90 76. GHK copper has been shown to increase collagen in one month by? A) 10% B) 20% C) 70% D) None of the above 77 / 90 77. Recommend dosing of DSIP with Glycine A) 100 mcg SQ qhs B) 100 mcg SQ 5 times a week C) 100 mcg SQ 2 times a week D) Start at 100 mcg SQ 2-3 times a week and then increase it to 200 mcg 2-3 times a week if necessary 78 / 90 78. Suggested first dosing of Bremelanotide PT 141 is A) 1 mg SQ 8 hours before event B) 1 mg SQ 1 hour before event C) 1 mg SQ at bedtime D) 1 mg SQ 10 minutes before event 79 / 90 79. During the study with Intranasal use of Bremelanotide PT 141 increased what? A) Glucose B) Blood pressure C) Headaches D) Cortisol 80 / 90 80. Melanontan 1 or Afamelanotide has been shown to improve what skin condition A) Vitiligo B) Psoriasis C) Hirsuitism D) Rosacea 81 / 90 81. Melanotan 1 and Melanotan 2 are derivatives of which hormone? A) ACTH B) Alpha Melanocyte stimulating hormone C) Beta Melanocyte stimulating hormone D) Gamma Melanocyte stimulating hormone 82 / 90 82. A recommended dosing of Epithalon A) 1 mg sq daily B) 5 mg sq daily for 10 days then repeat in 6 months C) 1 mg sq for 10 days and then repeat in 6 months D) 1 mg sq for 1 month and repeat in 1 year. 83 / 90 83. A published retrospective study on intra articular of BPC157 into the knee for knee joints a) No improvement in knee pain b) BPC157 made the knee pain worse c) Most patients had improvement in their knee pain 84 / 90 84. A possible dose of VIP is 50 mcg intra nasal twice to three times a day True False 85 / 90 85. Which answer or answers are false on Vasoactive Intestinal Peptide (VIP ) a) VIP has an inhibitory effects on macrophages and monocytes (VPAC 1 receptor) b) VIP lowers IL-10 c) VIP decreases T- regulatory cells d) VIP down regulates the Toll like receptors e) All of above f) B and C 86 / 90 86. What is true for Vasoactive Intestinal Peptide (VIP) a) Serum VIP levels are lower in ulcerative colitis patients compared to a healthy control b) In an animal study VIP treatment helped in mice model with Crohn’s disease c) Patients with lower VIP levels in Spondyloarthritis have more swelling and disability compared to a healthy control d) In animal studies VIP has shown to reduce inflammation in osteoarthritis and with rheumatoid arthritis 87 / 90 87. An acceptable dosing of MOTs-c is 10 mg SQ once a week 5 mg SQ 2 times a week 100 mg SQ once a week 50 mg SQ 2 times a week A and B C and D 88 / 90 88. MOTS- c levels are increased with aging? True False 89 / 90 89. MOTS- c can turn brown fat to white fat? True False 90 / 90 90. MOTS- c improve insulin resistance via which pathway Myostatin AMPK pathway PGC-1 A (Peroxisome proliferator gamma activated receptor coactivator 1 alpha) Uncoupling Factor 1 Your score is 0% Restart quiz
