Salt Lake City - 2026 - Essential Knowledge in the Clinical Use of Peptides Class

Salt Lake City - 2026 Essential Knowledge in the Clinical Use of Peptides Class
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1. According to the Human Proteome Map how many peptides do we approximately have?

A) 3,000

B) 30,000

C) 300,000

D) 3,000,000

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2. What is the most common receptor for peptides?

A) Tyrosine kinase receptor

B) Ion channel receptor

C) G Protein coupled receptor

D) All of the above

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3. Growth hormone releasing peptides (GHRP) stimulates what in the pituitary to release Growth hormone?

A) Cyclic AMP

B) Calcium

C) Magnesium

D) Zinc

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4. In the clinical trials with Thymulin in Rheumatoid Arthritis that used a dose of 5 mg SQ for weeks and then 3 times a week for 6 months showed:

A) No improvement

B) Improvement

C) Made it worse

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5. True or False: Thymulin is not zinc dependent

A) True

B) False

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6. An acceptable dosing of MOTS-c is

A) 10 mg SQ once a week

B) 5 mg SQ 2 times a week

C) 1 mg sq at bedtime 5 times a week

D) 50 mg SQ 2 times a week

E) A and B

F) C and D

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7. Which answer or answers are false on Vasoactive Intestinal Peptide (VIP )

A) VIP has an inhibitory effects on macrophages and monocytes (VPAC 1 receptor)

B) VIP lowers IL-10

C) VIP decreases T- regulatory cells

D) VIP down regulates the Toll like receptors

E) All of the above

F) B and C

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8. True or False : MOTS-c levels are increased with aging

A) True

B) False

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9. True or False : MOTS-c can turn white fat to brown fat?

A) True

B) False

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10. MOTS-c reduce insulin resistance via which pathway

A) Myostatin pathway

B) AMPK pathway

C) PCG-1A (Peroxiosome proliferator gamma activated receptor coactivator 1 alpha)

D) Uncoupling Factor 59 pathway

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11. MOTS-c can increase the biogenesis of the mitochondria via

A) PGC-1 (Peroxisome proliferator activated receptor gamma coactivator 1 -alpha)

B) AMPK

C) Tyrosine Kinase

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12. Although no formal GHK dosing for cancer has been established, anecdotal results have been observed at:

A) 2.5mg SQ 3 times per week

B) 0.5mg IM once weekly

C) 20mg IV bolus dose

D) None of the above

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13. Although multiple dosing regimens have been studied with TA1, an accepted dosing regimen in cancer management is:

A) 10mg IM weekly

B) 1.6mg SQ 2 times a week

C) 5mg IV daily

D) None of the above

14 / 40

14. GHK anticancer mechanism of action is:

A) Increased copper accumulation in cancer cells, resulting in cytotoxicity

B) Transmembrane cancer cell destabilization

C) Direct GHK peptide effects on cancer cell growth

D) Suppression of RNA production in overexpressed cancer genes

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15. Metenkephalin stimulates which of the following cancer inhibitory pathways?

A) P16

B) P23

C) P21

D) A and C

E) All of the above

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16. Which of the following doses of Metenkephalin has been studied clinically?

A) 1gm/kg

B) 2gm/kg

C) 250mcg/kg

D) 500mcg/kg

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17. Selank can be delivered

A) Oral

B) Intranasal

C) Subcutaneous

D) All of the above

E) B and C

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18. Selank main effect is that it helps with

A) Anxiety

B) Weight loss

C) Tanning

D) Improve libido

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19. Semax improved recovery in stroke, what doses did they use?

A) 12 mg for moderate stroke

B) 18 mg for severe stroke

C) 1000 mg for all stroke

D) A and B

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20. Dosing of Cerebrolysin in studies

A) 10 ml IV infusion 5 times a week

B) 20 ml IV infusion 5 times a week

C) 30 ml IV infusion 5 times a week

D) All of above

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21. Cerebrolysin in first degree relatives with Alzhemier’s showed after 1 month of Cerebrolysin at 20 ml/ day for 1 month

A) Improvement of cognitive function

B) No change in cognitive function

C) Decline in cognitive function

22 / 40

22. Typical dosing with BPC 157 for an acute musculoskeletal injury would be?

A) 100 mcg SQ once a day x 1 day

B) 200 mcg SQ once a day X 2 days

C) 300 mcg SQ once a day x 3 days

D) 1000 mcg SQ BID for 4-5 days

23 / 40

23. The mechanism of action of BPC 157 might be

A) Increase Growth Hormone receptors

B) Increase Nitric oxide

C) Increase the expression of early growth response 1 gene

D) Regulates the extracellular signal regulated kinases 1 and 2

E) All of the above

24 / 40

24. BPC 157 has been shown to

A) Increase pressure in lower esophageal sphincter (LES)

B) Increase pressure in the pyloric sphincter

C) Helps in healing fistulas

D) Normalize the LES pressure with NSAID- Nonsteroidal anti-inflammatory drugs

E) All of the above

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25. Recommended starting dose of MK-667 is

A) 2.5 mg

B) 12.5 mg

C) 25 mg

D) 100 mg

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26. MK-667 or Ibutamoren has side effects of

A) Increase hunger

B) Increase glucose

C) Heart failure

D) All of the above

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27. Tesamorelin recommended dosing is

A) 1 mg sq in the AM time every day

B) 1 mg sq at bedtime every night

C) 1 mg SQ at bedtime 5 times a week

D) 2000 micrograms by mouth at bedtime M-F

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28. Which peptides stimulates the Ghrelin receptor?

A) CJC 1295

B) Ipamorelin

C) Semorelin

D) Tesamorelin

E) B, C, D

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29. In a 2006 study with CJC-1295 with DAC looking at lipodystrophy in HIV patients there was one adverse side effect

A) Stroke

B) Kidney Failure

C) Heart attack

D) Liver Failure

30 / 40

30. CJC-1295 an analog of

A) Growth hormone releasing hormone

B) Growth hormone releasing peptide

C) Both

D) Neither

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31. The advantages of using peptides to stimulate growth hormone versus using human growth hormone

A) Release of 5 growth hormones from the pituitary gland

B) More physiologic in maintaining the pulsatile release of Growth hormone

C) Does not shut down the pituitary in releasing growth hormone

D) All of the above

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32. GHK copper has been shown to increase collagen in one month by?

A) 10%

B) 20%

C) 70%

D) None of the above

33 / 40

33. Suggested first dosing of Bremelanotide PT 141 is

A) 1 mg SQ 8 hours before event

B) 1 mg SQ 1 hour before event

C) 1 mg SQ at bedtime

D) 1 mg SQ 10 minutes before event

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34. Bremelanotide PT-141 is a derivative of which peptide

A) Melanotan 1

B) Melanotan 2

C) ACTH

D) None of the above

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35. Melanontan 1 or Afamelanotide has been shown to improve what skin condition

A) Vitiligo

B) Psoriasis

C) Hirsuitism

D) Rosacea

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36. A recommended dosing of Epithalon

A) 1 mg sq daily

B) 5 mg sq daily for 10 days then repeat in 6 months

C) 1 mg sq for 10 days and then repeat in 6 months

D) 1 mg sq for 1 month and repeat in 1 year.

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37. Epithalon has been shown to increase the telomeres by

A) 5%

B) 10%

C) 20%

D) 33%

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38. True or False Peptides are signaling molecules

A) True

B) False

39 / 40

39. A peptide bond is

A) Between a carboxyl group of one amino acid and another carboxyl group of another amino acid

B) Between an amino group of one amino acid and another amino group of another amino acid

C) Between a carboxyl group on one amino acid and amino group of another amino acid

D) Between a carboxyl group on one amino acid and the R side chain of another amino acid

40 / 40

40. Peptides are

A) Steroid structure

B) Made of amino acids that are over 100 amino acids long

C) Made of amino acids with glycosaminoglycan

D) None of the above

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