Longevity Certification – 2026 by peptidesociety | Jan 15, 2026 | Longevity Certification 67 Longevity Certification - 2026 2026 Essential Knowledge in the Longevity Certification Program After you answer the last question, please be patient while your test is being graded, it may take up to 1 minute before you know your results. Clinical Peptide Society Please enter the information below. 1 / 40 In the study of 10 patients taking a strawberry based Fisetin 500mg a day for 7 days per month after 6 months showed a. Everyone got younger in their biological age b. No change in their biological age c. 50% of the group got older in their biological age 2 / 40 In the largest human trial with using the senolytics, Dasatinib, Quercetin and Fisetin in 19 healthy subjects, the senolytics lowered biological age A) True B) False 3 / 40 In the PEARL study with rapamycin in humans 5 or 10 mg a week showed that it reduces biological age. A) True b) False 4 / 40 Can the Norwegian 4 x 4 minutes exercise 3 x week improve Vo2 Max? A) True B) False 5 / 40 What are tests can you use to test for longevity in your office? a. Grip strength test b. Balance with one leg and eyes are open c. Sit to Rise test d. Resting heart rate e. None of the above f. All of the above 6 / 40 Men in their 50’s with a resting heart rate of 75 beats per minute are twice as likely to die of a heart attack A) True B) False 7 / 40 The Yamanka factors are induced or activated by a. Supplements b. Diet c. Exercise d. None of the above e. All of the above 8 / 40 Which is ideal in using the Yamanka factors? a. Partial reprogramming b. Continuous reprogramming until pluripotent stem cells are reached c. It does not matter 9 / 40 In the vision restoration using 3 out of the 4 Yamnaka factors showed reprogramming of the epigenetics. Which statement or statements are true? a. The older retinal cells became younger through resetting their DNA methylation age b. In this study it was demonstrated that epignetic aging is reversible c. None of the above d. All of the above 10 / 40 Out of the 4 Yamanaka factors which one is linked to cancer a) Oct4 b) Sox2 c) C-Myc d) Klf4 11 / 40 About 20 years ago a fibroblast cell was converted into a pluripotent stem cell using Yamanaka factors A) True B) False 12 / 40 Hyperbaric oxygen therapy has not shown any evidence in improving cardiac function, cognition, erection, skin texture and Vo2 Max a) True b) False 13 / 40 The benefits of hypoxia-hyperoxia paradox are a. Angiogenesis b. Mitochondrial biogenesis c. Stem Cell release d. Increase in telomere lengths e. All of the above 14 / 40 Hyperbaric oxygen therapy can deliver 3- 4 x more oxygen than red blood cells can A) True B) False 15 / 40 Some of the genes that are turned on or off with HBOT a. Increase IL-6, IL-8, and TNF b. Increase in NRF-2, SOD and CAT c. Increase in VEGF, BDNF d. Decrease in IL-6, IL-10 and TNF e. A, B, C f. B, C, D 16 / 40 Higher atmosphere pressure results in lower arterial oxygen a) True B) False 17 / 40 In 2019 the Noble Prize of Medicine was awarded to group of scientists that discovered how cells can sense and adapt to changing oxygen availability. During the 1990s they identified a molecular machinery that regulates the activity of genes in response to varying levels of oxygen. What was that factor they discovered? a. Nitric oxide b. PGC-1 alpha c. HIF-1 alpha d. Humanin 18 / 40 Jeanne Calment is the oldest person in the world and lived to 122 years old. Her habits consisted of a. Smoke after meals and quit at age 117 b. Drank small amount of port wine after dinner c. Rode her bike to age 100 d. Prayed every morning e. Like to do crossword puzzles f. Avoided gluten g. A,B,C,D and E h. All of the above 19 / 40 The US spends the most money than any other country in healthcare and the US is ranked globally in life expectancy a. Number 1 b. Number 3 c. Number 10 d. the U.S. has the lowest life expectancy at birth among large, wealthy nations. 20 / 40 Testosterone replacement with patients being heterozygous for the HFE C28Y or H63D gene can unmask a. Skin Bronzing b. Cardiomyopathy c. Cirrhosis d. Diabetes Mellitus e. Hemochromatosis f. All of the above 21 / 40 People who have a ferritin level over 600 a. Live longer b. Shorter lifespan c. Has no correlation for survival 22 / 40 High Ferritin levels are associated with a. Reduced Reactive Oxygen Species (ROS) b. Increase in Oxidative stress c. Mitochondria Biogenesis d. Cardioprotective 23 / 40 The Recommended Daily Allowance of iron per day is a. 1 mg a day b. 8 mg a day c. 20 mg a day d. 100 mg a day 24 / 40 Cognitive Decline has not been reversed with using therapeutic plasma exchange True False 25 / 40 Microplastics has been linked to a. Cancer b. Heart disease c. Cognitive Decline d. There are no association with other chronic disease e. A, B and C 26 / 40 The Forever chemical PFAS can be removed from the body a. Chelation b. Oral Charcoal with Spirulina c. Session of 30 liver cleanse and coffee enemas d. Therapeutic plasma exchange 27 / 40 High protein intake alone has been established as a longevity strategy A) True B) False 28 / 40 After 60 years old it is harder to maintain muscle mass a. Not enough protein is eaten per day b. 1.0 gram of protein/kilogram of body per day is adequate c. 30 grams of protein a day is adequate d. Sarcopenia does not exist, since it is an internet myth 29 / 40 The top 5 diets for longevity consist of which one a. Mediterranean b. Ketogenic c. Vegetarian d. Caloric Restriction e. Fasting Mimicking diet f. All of the above a. A, C and D 30 / 40 Ultra-process foods have been linked to a) Obesity b) Chronic Inflammation c) Cancer d) Endothelial dysfunction e) Alteration to the microbiome f) All of the above g) A, B and C only 31 / 40 Which nutraceutical strategy is most synergistic with peptide-based mitochondrial therapeutics (e.g., SS-31 or MOTS-c) rather than redundant? a) Supraphysiologic antioxidant dosing to blunt ROS signaling b) NAD⁺ repletion combined with polyphenols that support redox cycling c) Chronic high-dose carnitine to increase fatty acid influx d) Exclusive reliance on CoQ10 to restore electron transport 32 / 40 Which mechanism best explains the mitochondrial benefit of SS-31 (elamipretide) in aging and chronic disease states? a) Activation of AMPK via mitochondrial DNA stress b) Stabilization of cardiolipin, improving electron transport chain efficiency and reducing ROS c) Upregulation of mitochondrial biogenesis through PGC-1α transcription d) Direct uncoupling of oxidative phosphorylation to reduce proton leak 33 / 40 What functional tests can you test for longevity in your office without using a devise a. Resting heart rate b. Hand Grip strength c. Sit to Stand test d. Vo2 max test e. One leg balance f. All of the above g. A, B, C, E h. None of the above 34 / 40 There are many human clinical trials that have shown statistically significant reduction in biological age with using senolytics or with rapamycin. A) True B) False 35 / 40 Which statement best differentiates cord plasma infusions from autologous PRP in longevity-oriented applications? a) Cord plasma contains developmentally enriched cytokines and trophic factors not present in adult autologous PRP b) PRP provides broader systemic immune rejuvenation than cord plasma c) Cord plasma is primarily platelet-derived, while PRP is cytokine-dominant d) PRP produces more durable systemic anti-aging effects than cord plasma 36 / 40 Which consideration is most critical when incorporating cord plasma infusions into a physician-led longevity program? a) HLA matching between donor and recipient b) Long-term immunosuppression following infusion c) Leukocyte depletion to prevent graft-versus-host disease d) Rigorous infectious screening, growth-signal risk assessment, and standardized dosing 37 / 40 Which proposed mechanism best explains the putative longevity effects observed in preclinical and early translational studies of cord plasma–derived products? a) Permanent engraftment of donor stem cells into host tissues b) Paracrine signaling via growth factors, extracellular vesicles, and anti-inflammatory cytokines c) Direct telomere lengthening through genomic integration d) Acute caloric-restriction–mimetic effects mediated by ketone induction 38 / 40 Which intervention has the strongest mechanistic and preclinical evidence for increasing endogenous Klotho expression or activity? a) High-dose calcium supplementation b) Chronic caloric restriction without resistance training c) RAAS inhibition and reduction of oxidative stress d) Supraphysiologic vitamin D dosing 39 / 40 Which of the following patient profiles is most appropriate for considering Klotho testing as part of a longevity-oriented or risk-stratification assessment? a) 35-year-old endurance athlete with normal labs and VO₂ max b) 48-year-old woman with isolated dyslipidemia responsive to statins c) 58-year-old man with insulin resistance, early CKD, sarcopenia, and elevated inflammatory markers d) 70-year-old woman with well-controlled hypertension only 40 / 40 A 62-year-old male with stage 3a chronic kidney disease (CKD), vascular calcifications on CT, elevated FGF23, and low-normal phosphate is found to have low circulating soluble Klotho. Which clinical interpretation is most accurate? a) Low Klotho primarily reflects reduced dietary phosphate intake b) Low Klotho suggests impaired renal endocrine function contributing to accelerated vascular aging c) Low Klotho is expected and clinically irrelevant in stage 3 CKD d) Low Klotho directly indicates parathyroid hormone resistance Your score is
